![]() Infiltration of transplanted ENCCs into the colon increased proportionally to the degree of dedifferentiation of surrounding smooth muscle cells, which was induced in a neurosphere-dependent manner in collagenase-treated colon. Invasion of neurospheres into colon was dependent on preoperative treatment of recipient colon with collagenase and fibronectin, which enhanced neurosphere motility towards the direction of colon lumen. Collagenase-treated colons exhibited enhanced expression of type III and VI collagens, which inhibited fibronectin-induced enteric neural crest cell (ENCC) migration. In this study, we used an ex vivo mouse colon transplant model to demonstrate that treatment with collagenase and fibronectin altered the migration of transplanted cells from the direction of the colon surface toward the lumen. Given their potential ability to replenish insufficient neurons, transplantation of enteric neural cells provides the prospect of a cure. Developmental ENS dysplasia causes intestinal ganglion dysfunction, including Hirschsprung's disease. The enteric nervous system (ENS) regulates gastrointestinal motility, secretion, and absorption.
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